Reciprocal regulation of mesenchymal stem cells and immune responses
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs
ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …
Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series
Background Acute respiratory distress syndrome (ARDS) is a fatal complication of
coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human …
coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human …
Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …
applications have greatly diversified during the past decade, including rapid growth of poorly …
Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept …
F Sánchez-Guijo, M García-Arranz… - …, 2020 - thelancet.com
Background Identification of effective treatments in severe cases of COVID-19 requiring
mechanical ventilation represents an unmet medical need. Our aim was to determine …
mechanical ventilation represents an unmet medical need. Our aim was to determine …
Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics
C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …
procedures–short “freeze-thawing”–are among the final steps in economically viable …
Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
studied for their therapeutic potential across a wide range of diseases. In the preclinical …