[HTML][HTML] Retinal stem cell transplantation: Balancing safety and potential
Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …
Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration
Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
EE Capowski, K Samimi, SJ Mayerl… - …, 2019 - journals.biologists.com
Numerous protocols have been described for producing neural retina from human
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …
Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs
Considerable progress has been made in testing stem cell–derived retinal pigment
epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD) …
epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD) …
Single-cell–resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity
Regional phenotypic and functional differences in the retinal pigment epithelium (RPE)
monolayer have been suggested to account for regional susceptibility in ocular diseases …
monolayer have been suggested to account for regional susceptibility in ocular diseases …
[HTML][HTML] Stem cell treatment of degenerative eye disease
Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …
Stem cell based therapies for age-related macular degeneration: the promises and the challenges
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
Abstract Age-related Macular Degeneration (AMD), a blinding eye disease, is characterized
by pathological protein-and lipid-rich drusen deposits underneath the retinal pigment …
by pathological protein-and lipid-rich drusen deposits underneath the retinal pigment …
[HTML][HTML] Primary cilium-mediated retinal pigment epithelium maturation is disrupted in ciliopathy patient cells
Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the
primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent …
primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent …
Cell-based therapy for degenerative retinal disease
M Zarbin - Trends in molecular medicine, 2016 - cell.com
Stem cell-derived retinal pigment epithelium (RPE) and photoreceptors (PRs) have restored
vision in preclinical models of human retinal degenerative disease. This review discusses …
vision in preclinical models of human retinal degenerative disease. This review discusses …