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Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)
COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …
Clinical course and management of COVID-19 in the era of widespread population immunity
The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in
humans. The current high levels of population immunity, due to prior infection and/or …
humans. The current high levels of population immunity, due to prior infection and/or …
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We
describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed …
describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed …
A simple, time-and cost-effective, high-throughput depletion strategy for deep plasma proteomics
We introduce a cost-effective, robust high-throughput–compatible plasma depletion method
enabling in-depth profiling of plasma that detects> 1300 proteins per run with a throughput …
enabling in-depth profiling of plasma that detects> 1300 proteins per run with a throughput …
Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by highly heterogeneous manifestations ranging from asymptomatic cases to death for still …
by highly heterogeneous manifestations ranging from asymptomatic cases to death for still …
Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the
mechanisms behind this relationship have remained incompletely understood. To address …
mechanisms behind this relationship have remained incompletely understood. To address …
Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality
BACKGROUND Patients hospitalized for COVID-19 exhibit diverse clinical outcomes, with
outcomes for some individuals diverging over time even though their initial disease severity …
outcomes for some individuals diverging over time even though their initial disease severity …
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
Mechanisms of long COVID: an updated review
Y Liu, X Gu, H Li, H Zhang, J Xu - Chinese Medical Journal …, 2023 - mednexus.org
The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3
years, with an enormous impact on global health and economies. In some patients …
years, with an enormous impact on global health and economies. In some patients …
Analytical challenges in omics research on asthma and allergy: a National Institute of Allergy and Infectious Diseases workshop
S Bunyavanich, PM Becker, MC Altman… - Journal of Allergy and …, 2024 - Elsevier
Studies of asthma and allergy are generating increasing volumes of omics data for analysis
and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) …
and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) …