Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

ZA Sherif, CR Gomez, TJ Connors, TJ Henrich… - Elife, 2023 - elifesciences.org
COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …

Clinical course and management of COVID-19 in the era of widespread population immunity

EA Meyerowitz, J Scott, A Richterman, V Male… - Nature Reviews …, 2024 - nature.com
The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in
humans. The current high levels of population immunity, due to prior infection and/or …

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

A Ozonoff, ND Jayavelu, S Liu, E Melamed… - Nature …, 2024 - nature.com
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We
describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed …

A simple, time-and cost-effective, high-throughput depletion strategy for deep plasma proteomics

A Viode, P van Zalm, KK Smolen, B Fatou… - Science …, 2023 - science.org
We introduce a cost-effective, robust high-throughput–compatible plasma depletion method
enabling in-depth profiling of plasma that detects> 1300 proteins per run with a throughput …

Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes

A Viode, KK Smolen, P van Zalm, D Stevenson… - Science …, 2024 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by highly heterogeneous manifestations ranging from asymptomatic cases to death for still …

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology

HV Phan, A Tsitsiklis, CP Maguire… - Science translational …, 2024 - science.org
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the
mechanisms behind this relationship have remained incompletely understood. To address …

Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality

JP Gygi, C Maguire, RK Patel, P Shinde… - The Journal of clinical …, 2024 - jci.org
BACKGROUND Patients hospitalized for COVID-19 exhibit diverse clinical outcomes, with
outcomes for some individuals diverging over time even though their initial disease severity …

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

J Diray-Arce, S Fourati, ND Jayavelu, R Patel… - Cell Reports …, 2023 - cell.com
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …

Mechanisms of long COVID: an updated review

Y Liu, X Gu, H Li, H Zhang, J Xu - Chinese Medical Journal …, 2023 - mednexus.org
The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3
years, with an enormous impact on global health and economies. In some patients …

Analytical challenges in omics research on asthma and allergy: a National Institute of Allergy and Infectious Diseases workshop

S Bunyavanich, PM Becker, MC Altman… - Journal of Allergy and …, 2024 - Elsevier
Studies of asthma and allergy are generating increasing volumes of omics data for analysis
and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) …