Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

An important goal of biomedical research is to translate basic research findings into useful
medical advances. In the field of neuropharmacology this requires understanding disease …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Reported herein is an unprecedented synthesis of C3‐fluorinated oxindoles through cross‐
dehydrogenative coupling of C (sp3)‐H and C (sp2)‐H bonds from malonate amides. Under …

The development of mild, efficient, and enantioselective methods for preparing chiral
fluorinated compounds has been a long‐standing challenge. Herein, we report a …

The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral
arterioles to dilate remain obscure. Here we show that modest elevation of extracellular …

Novel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating
dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and …

Alteplase (rt-PA) is the first therapy successfully developed for acute stroke therapy. The
success of rt-PA spurred development of new avenues for acute stroke management. For the …