The kidney proximal tubule is a key organ for human metabolism. The kidney responds to
stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate …

Introduction Most mammalian physiology is orchestrated by the circadian clock, including
drug transport and metabolism. As a result, efficacy and toxicity of many drugs are …

The molecular basis of circadian rhythm, driven by core clock genes such as Per1/2, has
been investigated on the transcriptome level, but not comprehensively on the proteome …

Kidney physiology shows diurnal variation, and a disrupted circadian rhythm is associated
with kidney disease. However, it remains largely unknown whether glomeruli, the filtering …

Dent disease (DD) is a hereditary renal disorder characterized by low molecular weight
(LMW) proteinuria and progressive renal failure. Inactivating mutations of the CLCN5 gene …

Daily rhythms in the activities of PERIOD proteins are critical to the temporal regulation of
mammalian physiology. While the molecular partners and genetic circuits that allow PERIOD …

Background: Autosomal dominant polycystic kidney disease (ADPKD) is caused by
mutations in the PKD1 and PKD2 genes, and often progresses to kidney failure. ADPKD …

Circadian rhythms are endogenous biological oscillations that regulate various
physiological processes in organisms, including kidney function. The kidney plays a vital …

Circadian rhythms influence a range of biological processes within the body, with the central
clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around …

Circadian disruption is a disturbance in biological timing, which can occur within or between
different organizational levels, ranging from molecular rhythms within specific cells to the …