Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
[HTML][HTML] Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the
transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical …
transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical …
[HTML][HTML] Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer
Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great
attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with …
attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with …
[HTML][HTML] Trends in drug-and vaccine-based dissolvable microneedle materials and methods of fabrication
Microneedle patches, also called microarray patches (MAP), are an emerging technology for
delivery and sampling of drugs, vaccines and other materials. This review focuses on the …
delivery and sampling of drugs, vaccines and other materials. This review focuses on the …
Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of poorly soluble cabotegravir sodium for HIV Pre-Exposure Prophylaxis
Hydrogel-forming microarray patches (HF-MAPs) offer minimally invasive, pain-free and
prolonged drug delivery. These devices are designed to be self-administered and self …
prolonged drug delivery. These devices are designed to be self-administered and self …
Hydrogel-forming microneedles for rapid and efficient skin deposition of controlled release tip-implants
In this work, we introduce, for the first time, novel hybrid microneedle patches with
implantable poly (lactic-co-glycolic acid)(PLGA) tips aligned with hydrogel-forming …
implantable poly (lactic-co-glycolic acid)(PLGA) tips aligned with hydrogel-forming …
Ring inserts as a useful strategy to prepare tip-loaded microneedles for long-acting drug delivery with application in HIV pre-exposure prophylaxis
The role of microneedle array patches (MAPs) and, in particular, dissolving MAPs in
transdermal drug delivery has increased exponentially over the last decade. MAPs are able …
transdermal drug delivery has increased exponentially over the last decade. MAPs are able …
Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both
humans and animals' lives. Current treatment of CE by oral administration of albendazole …
humans and animals' lives. Current treatment of CE by oral administration of albendazole …
[HTML][HTML] Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium …
Malaria is a global parasitic infection that leads to substantial illness and death. The most
commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but …
commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but …
Where microneedle meets biomarkers: futuristic application for diagnosing and monitoring localized external organ diseases
Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists'
interest. Many significant biomarkers for localized external organ diseases have been …
interest. Many significant biomarkers for localized external organ diseases have been …