Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Treatments that target immune checkpoints, such as the one mediated by programmed cell
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …

Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

The bromodomain and extraterminal (BET) family of proteins comprises four members—
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …

Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …

Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer.
Here, we describe a mouse model showing that mutant SPOP drives prostate tumorigenesis …