Sequence representation approaches for sequence-based protein prediction tasks that use deep learning

F Cui, Z Zhang, Q Zou - Briefings in Functional Genomics, 2021 - academic.oup.com
Deep learning has been increasingly used in bioinformatics, especially in sequence-based
protein prediction tasks, as large amounts of biological data are available and deep learning …

A comprehensive review of the imbalance classification of protein post-translational modifications

L Dou, F Yang, L Xu, Q Zou - Briefings in Bioinformatics, 2021 - academic.oup.com
Post-translational modifications (PTMs) play significant roles in regulating protein structure,
activity and function, and they are closely involved in various pathologies. Therefore, the …

MK-FSVM-SVDD: a multiple kernel-based fuzzy SVM model for predicting DNA-binding proteins via support vector data description

Y Zou, H Wu, X Guo, L Peng, Y Ding… - Current …, 2021 - ingentaconnect.com
Background: Detecting DNA-binding proteins (DBPs) based on biological and chemical
methods is time-consuming and expensive. Objective: In recent years, the rise of …

Anticancer peptides prediction with deep representation learning features

Z Lv, F Cui, Q Zou, L Zhang, L Xu - Briefings in bioinformatics, 2021 - academic.oup.com
Anticancer peptides constitute one of the most promising therapeutic agents for combating
common human cancers. Using wet experiments to verify whether a peptide displays …

sgRNACNN: identifying sgRNA on-target activity in four crops using ensembles of convolutional neural networks

M Niu, Y Lin, Q Zou - Plant molecular biology, 2021 - Springer
Key message We proposed an ensemble convolutional neural network model to identify
sgRNA high on-target activity in four crops and we used one-hot encoding and k-mers for …

Identification of sub-Golgi protein localization by use of deep representation learning features

Z Lv, P Wang, Q Zou, Q Jiang - Bioinformatics, 2020 - academic.oup.com
Abstract Motivation The Golgi apparatus has a key functional role in protein biosynthesis
within the eukaryotic cell with malfunction resulting in various neurodegenerative diseases …

iTTCA-RF: a random forest predictor for tumor T cell antigens

S Jiao, Q Zou, H Guo, L Shi - Journal of translational medicine, 2021 - Springer
Background Cancer is one of the most serious diseases threatening human health. Cancer
immunotherapy represents the most promising treatment strategy due to its high efficacy and …

[HTML][HTML] Prediction of antioxidant proteins using hybrid feature representation method and random forest

C Ao, W Zhou, L Gao, B Dong, L Yu - Genomics, 2020 - Elsevier
Natural antioxidant proteins are mainly found in plants and animals, which interact to
eliminate excessive free radicals and protect cells and DNA from damage, prevent and treat …

ML-FGAT: Identification of multi-label protein subcellular localization by interpretable graph attention networks and feature-generative adversarial networks

C Wang, Y Wang, P Ding, S Li, X Yu, B Yu - Computers in Biology and …, 2024 - Elsevier
The prediction of multi-label protein subcellular localization (SCL) is a pivotal area in
bioinformatics research. Recent advancements in protein structure research have facilitated …

DeepLncLoc: a deep learning framework for long non-coding RNA subcellular localization prediction based on subsequence embedding

M Zeng, Y Wu, C Lu, F Zhang, FX Wu… - Briefings in …, 2022 - academic.oup.com
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with more than 200
nucleotides. A growing amount of evidence reveals that subcellular localization of lncRNAs …