Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …

The technique of attaching the polymer polyethylene glycol (PEG), or PEGylation, has
brought more than ten protein drugs into market. The surface conjugation of PEG on proteins …

Highlights•Limitations of conjugating poly (ethylene glycol) to proteins and peptides have
become increasingly apparent.•Various polymers have shown promise as PEG …

XTEN™ is a class of unstructured hydrophilic, biodegradable protein polymers designed to
increase the half-lives of therapeutic peptides and proteins. XTEN polymers and XTEN …

Highlights•Compares and contrasts new affinity methods to dominant conventional
methods.•Explains how the popular His tag, despite its age, still dominates this …

Anoctamins are a family of Ca 2+-activated proteins that may act as ion channels and/or
phospholipid scramblases with limited understanding of function and disease association …

Protein therapeutics have gained momentum in recent years and become a pillar in treating
many diseases and the only choice in several ailments. Protein therapeutics are highly …

The supply of oxygen and nutrients to the brain is vital for its function and requires a complex
vascular network that, when disturbed, results in profound neurological dysfunction. As part …

Biological drugs or biopharmaceuticals off patent open a large market for biosimilars and
biobetters, follow-on biologics. Biobetters, in particular, are new drugs designed from …

Although polyethylene glycol (PEG), or “PEGylation” has become a widely applied approach
for improving the efficiency of drug delivery, the immunogenicity and non-biodegradability of …