Bone is formed by a series of complex events involving the mineralization of extracellular
matrix proteins rigidly orchestrated by cells with specific functions of maintaining the integrity …

A strong interest in use of ceramics for biomedical applications appeared in the late 1960's.
Used initially as alternatives to metals in order to increase a biocompatibility of implants …

To the Editor: The reconstruction of large bone segments is an important clinical problem,
and none of the approaches proposed thus far have proved very effective. In animals, repair …

Hydroxyapatite (HA) is an essential element required for bone regeneration. Different forms
of HA have been used for a long time. The essence of bone regeneration always revolves …

The ability of marrow‐derived osteoprogenitor cells to promote repair of critical‐size tibial
gaps upon autologous transplantation on a hydroxyapatite ceramic (HAC) carrier was tested …

Extensive bone loss is still a major problem in orthopedics. A number of different therapeutic
approaches have been developed and proposed, but so far none have proven to be fully …

In the US, 30% of adults suffer joint pain, most commonly in the knee, which severely limits
mobility and is often attributed to injury of cartilage and underlying bone in the joint. Current …

Trauma and disease of bones and joints, frequently involving structural damage to both the
articular cartilage surface and the subchondral bone, result in severe pain and disability for …

In the last five decades, there have been vast advances in the field of biomaterials, including
ceramics, glasses, glass-ceramics and metal alloys. Dense and porous ceramics have been …

The repair of large segmental bone defects due to trauma, inflammation and tumor surgery
remains a major clinical problem. Animal models were developed to test bone repair by …