Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Background Genome-wide association studies have enabled Mendelian randomization
analyses to be performed at an industrial scale. Two-sample summary data Mendelian …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …

Background Epidemiological evidence links a close correlation between long-term exposure
to air pollutants and autoimmune diseases, while the causality remained unknown. Methods …

Background While circulating metabolites have been increasingly linked to cancer risk, the
causality underlying these associations remains largely uninterrogated. Methods We …

Importance Lipid pathways have been implicated in the pathogenesis of psoriasis, and
some lipid-lowering drugs, such as statins, are hypothesized to have disease-modifying …

Background: Calcific aortic stenosis (CAS) is the most common valvular heart disease in
older adults and has no effective preventive therapies. Genome-wide association studies …

Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise in
reducing the risk of atrial fibrillation (AF). However, the results are controversial and the …

Metabolic syndrome, today affecting more than 20% of the US population, is a group of 5
conditions that often coexist and that strongly predispose to cardiovascular disease. How …