Highlights•Unpredictable Ebola epidemics hamper determination of vaccine
efficacy.•Ervebo and Zabdeno/Mvabea vaccines receive approval for use.•Approved Ebola …

Importance Extenuating circumstances can trigger unplanned changes to randomized trials
and introduce methodological, ethical, feasibility, and analytical challenges that can …

Background Major infectious disease outbreaks are a constant threat to human health.
Clinical research responses to outbreaks generate evidence to improve outcomes and …

Background The COVID-19 pandemic presents significant challenges to research ethics
committees (RECs) in balancing urgency of review of COVID-19 research with careful …

Background Ensuring that countries have adequate research capacities is essential for an
effective and efficient response to infectious disease outbreaks. The need for ethical …

Background For 30 years, women have sought equal opportunity to be included in trials so
that drugs are equitably studied in women as well as men; regulatory guidelines have …

Background. Biobanks are imperative infrastructures, particularly during outbreaks, when
there is an obligation to acquire and share knowledge as quick as possible to allow for …

Observational studies must be reformed before the next pandemic | Nature Medicine Skip to
main content Thank you for visiting nature.com. You are using a browser version with limited …

The coronavirus disease 2019 (COVID-19) pandemic has significant health and economic
ramifications across sub-Saharan Africa (SSA). Data regarding its far-reaching impacts are …

The twentieth century witnessed a succession of heinous experiments on human subjects in
the name of science. The deplorable nature of these experiments led to the development of …