[HTML][HTML] The influence of strontium on bone tissue metabolism and its application in osteoporosis treatment

B Kołodziejska, N Stępień, J Kolmas - International Journal of Molecular …, 2021‏ - mdpi.com
Osteoporosis is a chronic disease characterized by low bone mass caused by increased
bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or …

[HTML][HTML] A review of the latest insights into the mechanism of action of strontium in bone

D Marx, AR Yazdi, M Papini, M Towler - Bone reports, 2020‏ - Elsevier
Interest in strontium (Sr) has persisted over the last three decades due to its unique
mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast …

[HTML][HTML] Effects of silicon compounds on biomineralization, osteogenesis, and hard tissue formation

W Götz, E Tobiasch, S Witzleben, M Schulze - Pharmaceutics, 2019‏ - mdpi.com
Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The
synthesis and fabrication of appropriate scaffold materials, their analytical characterization …

Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis

Z Saidak, PJ Marie - Pharmacology & therapeutics, 2012‏ - Elsevier
Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

A materials science vision of extracellular matrix mineralization

N Reznikov, JAM Steele, P Fratzl… - Nature Reviews …, 2016‏ - nature.com
From an engineering perspective, skeletal tissues are remarkable structures because they
are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical …

Infrared assessment of bone quality: a review

EP Paschalis, R Mendelsohn… - … and Related Research®, 2011‏ - journals.lww.com
Background Bone strength depends on both bone quantity and quality. The former is
routinely estimated in clinical settings through bone mineral density measurements but not …

How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis

PJ Marie, D Felsenberg, ML Brandi - Osteoporosis International, 2011‏ - Springer
Oestrogen deficiency increases the rate of bone remodelling which, in association with a
negative remodelling balance (resorption exceeding formation), results in impaired bone …

[HTML][HTML] Spatial distribution of the trace elements zinc, strontium and lead in human bone tissue

B Pemmer, A Roschger, A Wastl, JG Hofstaetter… - Bone, 2013‏ - Elsevier
Trace elements are chemical elements in minute quantities, which are known to accumulate
in the bone. Cortical and trabecular bones consist of bone structural units (BSUs) such as …

The effects of strontium on bone mineral: A review on current knowledge and microanalytical approaches

W Querido, AL Rossi, M Farina - Micron, 2016‏ - Elsevier
The interest in effects of strontium (Sr) on bone has greatly increased in the last decade due
to the development of the promising drug strontium ranelate. This drug is used for treating …

Biomineralization‐inspired material design for bone regeneration

D de Melo Pereira, P Habibovic - Advanced healthcare …, 2018‏ - Wiley Online Library
Synthetic substitutes of bone grafts, such as calcium phosphate–based ceramics, have
shown some good clinical successes in the regeneration of large bone defects and are …