Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022‏ - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Anticancer drug discovery based on natural products: From computational approaches to clinical studies

P Chunarkar-Patil, M Kaleem, R Mishra, S Ray… - Biomedicines, 2024‏ - mdpi.com
Globally, malignancies cause one out of six mortalities, which is a serious health problem.
Cancer therapy has always been challenging, apart from major advances in …

[HTML][HTML] The coming decade of cell death research: five riddles

DR Green - Cell, 2019‏ - cell.com
Active cell death, in its many forms, is a fundamental biological process. Studies over the
past several decades have explored the functions and consequences of cellular demise and …

[HTML][HTML] Anticancer activity of propolis and its compounds

E Forma, M Bryś - Nutrients, 2021‏ - mdpi.com
Propolis is a natural material that honey bees (Apis mellifera) produce from various
botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and …

Autophagy and organelle homeostasis in cancer

DR Miller, A Thorburn - Developmental cell, 2021‏ - cell.com
Beginning with the earliest studies of autophagy in cancer, there have been indications that
autophagy can both promote and inhibit cancer growth and progression; autophagy …

The role of interaction between autophagy and apoptosis in tumorigenesis

H **, S Wang, B Wang, X Hong, X Liu… - Oncology …, 2022‏ - spandidos-publications.com
Autophagy is a highly conserved process that maintains cellular homeostasis during
evolution. Autophagy can occur in the form of macroautophagy, microautophagy or …

The function of natural compounds in important anticancer mechanisms

Y Nan, H Su, B Zhou, S Liu - Frontiers in Oncology, 2023‏ - frontiersin.org
The existence of malignant tumors has been a threat to human life, health, and safety.
Although the rapid development of radiotherapy, drug therapy, surgery, and local therapy …

Targeting of cancer cell death mechanisms by resveratrol: A review

X Fu, M Li, C Tang, Z Huang, M Najafi - Apoptosis, 2021‏ - Springer
Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce
apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free …

Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

W Jiang, J **a, S **e, R Zou, S Pan, Z Wang… - Drug Resistance …, 2020‏ - Elsevier
Chemoresistance including intrinsic and acquired anticancer drug resistance continues to
be a primary hindrance towards curative cancer treatment. Therefore, deciphering the …

Mitochondria and inflammation: cell death heats up

E Vringer, SWG Tait - Frontiers in cell and developmental biology, 2019‏ - frontiersin.org
Mitochondrial outer membrane permeabilization (MOMP) is essential to initiate
mitochondrial apoptosis. Due to the disruption of mitochondrial outer membrane integrity …