Head and neck cancer: The role of anti-EGFR agents in the era of immunotherapy

M Fasano, CM Della Corte, G Viscardi… - … in medical oncology, 2021 - journals.sagepub.com
Head and neck cancers (HNC) represent the seventh most frequent cancer worldwide, with
squamous cell carcinomas as the most frequent histologic subtype. Standard treatment for …

DNA damage response mechanisms in head and neck cancer: significant implications for therapy and survival

C Papalouka, M Adamaki, P Batsaki… - International Journal of …, 2023 - mdpi.com
Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …

Current and emerging molecular therapies for head and neck squamous cell carcinoma

F Kordbacheh, CS Farah - Cancers, 2021 - mdpi.com
Simple Summary Next-generation sequencing of head and neck squamous cell carcinoma
has revealed multiple new gene mutations, while simultaneously confirming the role of …

Analyzing expression and phosphorylation of the EGF receptor in HNSCC

M Kriegs, TS Clauditz, K Hoffer, J Bartels, S Buhs… - Scientific reports, 2019 - nature.com
Overexpression of the epidermal growth factor receptor (EGFR) in head and neck squamous
cell carcinomas (HNSCC) is considered to cause increased EGFR activity, which adds to …

HPV-related Sinonasal Carcinoma: Clinicopathologic Features, Diagnostic Utility of p16 and Rb Immunohistochemistry, and: EGFR: Copy Number Alteration

R Jiromaru, H Yamamoto, R Yasumatsu… - The American Journal …, 2020 - journals.lww.com
The prevalence and prognostic value of human papillomavirus (HPV) infection and
epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma …

Shooting at moving and hidden targets—tumour cell plasticity and the notch signalling pathway in head and neck squamous cell carcinomas

J Kałafut, A Czerwonka, A Anameriç… - Cancers, 2021 - mdpi.com
Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …

Clinicopathologic significance of EGFR mutation and HPV infection in sinonasal squamous cell carcinoma

T Hongo, H Yamamoto, R Jiromaru… - The American Journal …, 2021 - journals.lww.com
Sinonasal squamous cell carcinoma (SNSCC) is sometimes associated with high-risk
human papillomavirus (HR-HPV) infection and inverted sinonasal papilloma or oncocytic …

Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance

E Muraro, G Fanetti, V Lupato, V Giacomarra… - Critical Reviews in …, 2021 - Elsevier
Since its introduction, the use of cetuximab in the treatment of head and neck squamous cell
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …

A systematic literature review of the human papillomavirus prevalence in locally and regionally advanced and recurrent/metastatic head and neck cancers through the …

S Agelaki, I Boukovinas, I Athanasiadis… - Cancer …, 2024 - Wiley Online Library
Aims The aim of this systematic literature review was to provide updated information on
human papillomavirus (HPV) prevalence in locally and regionally advanced (LA) and …

[HTML][HTML] Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer

M Calheiros-Lobo, JPN Silva, B Pinto, L Monteiro… - Pharmaceutics, 2024 - mdpi.com
Head and neck cancer (HNC), the sixth most common cancer worldwide, is increasing in
incidence, with oral squamous cell carcinoma (OSCC) as the predominant subtype. OSCC …