RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

K Wu, X Lin, Y Lu, R Dong, H Jiang… - Nature …, 2024 - nature.com
Abstract Hypervirulent Klebsiella pneumoniae (HvKP) is an emerging bacterial pathogen
causing invasive infection in immune-competent humans. The hypervirulence is strongly …

[HTML][HTML] A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks of Klebsiella pneumoniae in ICUs

TA Chen, YT Chuang, CH Lin - Microorganisms, 2024 - mdpi.com
Klebsiella pneumoniae, a major opportunistic pathogen, causes severe infections in both
community and healthcare settings, especially in intensive care units (ICUs), where …

Klebsiella pneumoniae capsular polysaccharide: Mechanism in regulation of synthesis, virulence, and pathogenicity

L Xu, J Li, W Wu, X Wu, J Ren - Virulence, 2024 - Taylor & Francis
Hypervirulent Klebsiella pneumoniae exhibits strong pathogenicity and can cause severe
invasive infections but is historically recognized as antibiotic-susceptible. In recent years, the …

RIL-seq reveals extensive involvement of small RNAs in virulence and capsule regulation in hypervirulent Klebsiella pneumoniae

KJ Goh, Y Altuvia, L Argaman, Y Raz, A Bar… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Hypervirulent Klebsiella pneumoniae (hv Kp) can infect healthy individuals, in
contrast to classical strains that commonly cause nosocomial infections. The recent …

Inorganic Polyphosphate Affects Biofilm Assembly, Capsule Formation, and Virulence of Hypervirulent ST23 Klebsiella pneumoniae

D Rojas, AE Marcoleta, M Gálvez-Silva… - ACS Infectious …, 2024 - ACS Publications
The emergence of hypervirulent Klebsiella pneumoniae (hvKP) strains poses a significant
threat to public health due to high mortality rates and propensity to cause severe community …

Microaerobic-mediated suppression of Klebsiella pneumoniae mucoviscosity is restored by rmpD overexpression

W Sun, C Rong, L Chen, J Li, Z An, J Yue… - Journal of Applied …, 2024 - academic.oup.com
Abstract Aims Hypervirulent Klebsiella pneumoniae (hvKp) causes invasive community-
acquired infections in healthy individuals, and hypermucoviscosity (HMV) is the main …

Adaptive attenuation of virulence in hypervirulent carbapenem-resistant Klebsiella pneumoniae

G Teng, M Zhang, YY Fu, X Yang, Y Kang, Q Qin… - Msystems, 2024 - Am Soc Microbiol
The emergence of nosocomial infections caused by hypervirulent and carbapenem-resistant
K. pneumoniae (hv-CRKP) has become a significant public health challenge. The genetic …

Analysis of the virulence of a lethal, carbapenem-resistant hypervirulent KPC-33-producing Klebsiella pneumoniae: Emergence of ST11-KL64 hv-CRKP in ICU

Y Yan, N Kong, Y Niu, K Sun, W Zhang - Microbial Pathogenesis, 2025 - Elsevier
Objective Hypervirulent and carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) poses
a serious threat to public health. Here, we analyse a case of systemic infection caused by a …

Mechanisms of Plasmid Behavioral Manipulation

JG Malone, CMA Thompson - DNA and Cell Biology, 2024 - liebertpub.com
A key way in which bacteria can adapt to environmental pressures is by acquiring new
genetic information through horizontal gene transfer (Rodriguez-Beltran et al., 2021). This …

Emergence of novel non-aggregative variants under negative frequency-dependent selection in Klebsiella variicola

A Nucci, J Janaszkiewicz, EPC Rocha, O Rendueles - Microlife, 2023 - academic.oup.com
Klebsiella variicola is an emergent human pathogen causing diverse infections, some of
which in the urinary tract. However, little is known about the evolution and maintenance of …