[HTML][HTML] Personalized dosimetry in targeted radiation therapy: a look to methods, tools and critical aspects

R Danieli, A Milano, S Gallo, I Veronese… - Journal of Personalized …, 2022 - mdpi.com
Targeted radiation therapy (TRT) is a strategy increasingly adopted for the treatment of
different types of cancer. The urge for optimization, as stated by the European Council …

The impact of radiopharmaceutical therapy on renal function

EA Park, SA Graves, Y Menda - Seminars in nuclear medicine, 2022 - Elsevier
Radiopharmaceuticals used for cancer therapy are highly selective, designed to kill
malignant cells and spare healthy tissues. Side effect rates are generally less than other …

A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project

J Tran-Gia, AM Denis-Bacelar, KM Ferreira… - EJNMMI physics, 2021 - Springer
Purpose Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy
and to predict response. Dosimetry involves several steps, the first of which is the …

Comparison of commercial dosimetric software platforms in patients treated with 177Lu‐DOTATATE for peptide receptor radionuclide therapy

E Mora‐Ramirez, L Santoro, E Cassol… - Medical …, 2020 - Wiley Online Library
Purpose The aim of this study was to quantitatively compare five commercial dosimetric
software platforms based on the analysis of clinical datasets of patients who benefited from …

Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas

M Tulik, R Kuliński, Z Tabor, B Brzozowska, P Łaba… - EJNMMI physics, 2024 - Springer
Background A new, alternative option for patients with recurrent glioblastoma is targeted
alpha therapy (TAT), in the form of a local administration of substance P (neurokinin type 1 …

Implementation of patient dosimetry in the clinical practice after targeted radiotherapy using [177Lu-[DOTA0, Tyr3]-octreotate

L Santoro, E Mora-Ramirez, D Trauchessec, S Chouaf… - EJNMMI research, 2018 - Springer
Background This study's aim was to develop our dosimetric methodology using a
commercial workstation for the routine evaluation of the organs at risk during peptide …

3-D image-based dosimetry in radionuclide therapy

M Ljungberg, KS Gleisner - IEEE Transactions on Radiation …, 2018 - ieeexplore.ieee.org
Radionuclide therapy is the use of radioactive drugs for internal radiotherapy, mainly for the
treatment of metastatic disease. As opposed to systemic cancer therapies in general, the use …

Accuracy of kidney dosimetry performed using simplified time activity curve modelling methods: a 177Lu-DOTATATE patient study

W Zhao, PL Esquinas, A Frezza, X Hou… - Physics in Medicine …, 2019 - iopscience.iop.org
Abstract 177 Lu-DOTATATE therapy has been shown to produce encouraging results in
treatment of neuroendocrine tumours (NETs). Unfortunately, since dosimetry for radionuclide …

Clinical implementation of PLANET® Dose for dosimetric assessment after [177Lu]Lu-DOTA-TATE: comparison with Dosimetry Toolkit® and OLINDA/EXM® V1.0

L Santoro, L Pitalot, D Trauchessec, E Mora-Ramirez… - EJNMMI research, 2021 - Springer
Background The aim of this study was to compare a commercial dosimetry workstation
(PLANET® Dose) and the dosimetry approach (GE Dosimetry Toolkit® and OLINDA/EXM® …

Comprehensive SPECT/CT system characterization and calibration for 177Lu quantitative SPECT (QSPECT) with dead-time correction

A Frezza, C Desport, C Uribe, W Zhao, A Celler… - EJNMMI physics, 2020 - Springer
Abstract Background Personalization of 177 Lu-based radionuclide therapy requires
implementation of dosimetry methods that are both accurate and practical enough for routine …