The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken - Nature Reviews Immunology, 2018 - nature.com
T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
PD-1 and its ligands in tolerance and immunity
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that
regulate the balance between T cell activation, tolerance, and immunopathology. Immune …
regulate the balance between T cell activation, tolerance, and immunopathology. Immune …
The B7 family revisited
RJ Greenwald, GJ Freeman, AH Sharpe - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The discovery of new functions for the original B7 family members, together with
the identification of additional B7 and CD28 family members, have revealed new ways in …
the identification of additional B7 and CD28 family members, have revealed new ways in …
Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: results from the phase I/II CheckMate 358 trial
PURPOSE Nivolumab was assessed in patients with virus-associated tumors in the phase
I/II CheckMate 358 trial (ClinicalTrials. gov identifier: NCT02488759). We report on patients …
I/II CheckMate 358 trial (ClinicalTrials. gov identifier: NCT02488759). We report on patients …
The PD1: PD-L1/2 pathway from discovery to clinical implementation
The immune system maintains a critically organized network to defend against foreign
particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors …
particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors …
Advances in graft-versus-host disease biology and therapy
Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …
Ipilimumab for patients with relapse after allogeneic transplantation
Background Loss of donor-mediated immune antitumor activity after allogeneic
hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We …
hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We …
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
L Chen - Nature Reviews Immunology, 2004 - nature.com
Co-signalling molecules are cell-surface glycoproteins that can direct, modulate and fine-
tune T-cell receptor (TCR) signals. On the basis of their functional outcome, co-signalling …
tune T-cell receptor (TCR) signals. On the basis of their functional outcome, co-signalling …
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation
C Toffalori, L Zito, V Gambacorta, M Riba, G Oliveira… - Nature medicine, 2019 - nature.com
Transplantation of hematopoietic cells from a healthy individual (allogeneic hematopoietic
cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood …
cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood …
PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas
A Goodman, SP Patel, R Kurzrock - Nature reviews Clinical oncology, 2017 - nature.com
Cancer cells can escape T-cell-mediated cellular cytotoxicity by exploiting the inhibitory
programmed cell-death protein 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) immune …
programmed cell-death protein 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) immune …