Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

Throughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for
their ability to produce bioactive metabolites. Yet, this success has been hampered by …

Microorganisms produce small bioactive compounds as part of their secondary or
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …

Many microorganisms produce natural products that are frequently used in the development
of medicines and crop protection agents. Genome mining has evolved into a prominent …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Natural ecosystems harbor a huge reservoir of taxonomically diverse microbes that are
important for plant growth and health. The vast diversity of soil microorganisms and their …

Covering: 2000 to 2023 Cyanobacteria produce a variety of bioactive natural products that
can pose a threat to humans and animals as environmental toxins, but also have potential …

Deazaguanine modifications play multifaceted roles in the molecular biology of DNA and
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …

Eusocial pollinators are crucial elements in global agriculture. The honeybees and
bumblebees are associated with a simple yet host-restricted gut community, which protect …

Secondary metabolites are compounds not essential for an organism's development, but
provide significant ecological and physiological benefits. These compounds have …