Control of innate immune response by biomaterial surface topography, energy, and stiffness

JO Abaricia, N Farzad, TJ Heath, J Simmons… - Acta Biomaterialia, 2021 - Elsevier
As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

Electrochemical surface engineering of titanium-based alloys for biomedical application

A Gao, R Hang, L Bai, B Tang, PK Chu - Electrochimica Acta, 2018 - Elsevier
Titanium (Ti) and its alloys are the most widely used materials for biomedical applications,
owing to their good corrosion resistance, mechanical properties, and biocompatibility …

Aligned metal oxide nanotube arrays: key-aspects of anodic TiO 2 nanotube formation and properties

F Riboni, NT Nguyen, S So, P Schmuki - Nanoscale Horizons, 2016 - pubs.rsc.org
Over the past ten years, self-aligned TiO2 nanotubes have attracted tremendous scientific
and technological interest due to their anticipated impact on energy conversion …

Surface engineering for dental implantology: Favoring tissue responses along the implant

BAJA Van Oirschot, Y Zhang, HS Alghamdi… - … Engineering Part A, 2022 - liebertpub.com
Dental implants represent an illustrative example of successful medical devices used in
increasing numbers to aid (partly) edentulous patients. Particularly in spite of the …

Corrosion, antibacterial activity and haemocompatibility of TiO2 nanotubes as a function of their annealing temperature

A Mazare, G Totea, C Burnei, P Schmuki, I Demetrescu… - Corrosion …, 2016 - Elsevier
The present work reports on the corrosion behavior and antibacterial activity of self-
organized TiO 2 nanotubes in dependence of annealing temperature. TiO 2 nanotubes are …

[HTML][HTML] Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery

J Park, A Cimpean, AB Tesler, A Mazare - Nanomaterials, 2021 - mdpi.com
TiO2 nanostructures and more specifically nanotubes have gained significant attention in
biomedical applications, due to their controlled nanoscale topography in the sub-100 nm …

Osteointegration of Ti bone implants: A study on how surface parameters control the foreign body response

A Mesa-Restrepo, E Byers, JL Brown… - ACS Biomaterials …, 2024 - ACS Publications
The integration of titanium (Ti)-based implants with bone is limited, resulting in implant
failure. This lack of osteointegration is due to the foreign body response (FBR) that occurs …

Attenuation of the macrophage inflammatory activity by TiO2 nanotubes via inhibition of MAPK and NF-κB pathways

P Neacsu, A Mazare, P Schmuki… - International journal of …, 2015 - Taylor & Francis
Biomaterial implantation in a living tissue triggers the activation of macrophages in
inflammatory events, promoting the transcription of pro-inflammatory mediator genes. The …

Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration

Y He, Y Gao, Q Ma, X Zhang, Y Zhang… - Journal of …, 2022 - Springer
Nanotopographical cues of bone implant surface has direct influences on various cell types
during the establishment of osseointegration, a prerequisite of implant bear-loading. Given …

Formation and biological activities of foreign body giant cells in response to biomaterials

F Cai, B Jiang, F He - Acta Biomaterialia, 2024 - Elsevier
The integration of biomaterials in medical applications triggers the foreign body response
(FBR), a multi-stage immune reaction characterized by the formation of foreign body giant …