Abstract “Conservation genomics” encompasses the idea that genome-scale data will
improve the capacity of resource managers to protect species. Although genetic approaches …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

Living things are organized in a hierarchy of levels. Genes group together in cells, cells
group together in organisms, and organisms group together in societies. Even different …

MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …

Recent increases in the magnitude and rate of environmental change, including habitat loss,
climate change and overexploitation, have been directly linked to the global loss of …

Clonally transmissible cancers are somatic cell lineages that are spread between
individuals via the transfer of living cancer cells. There are only three known naturally …

Summary The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is
endangered due to a transmissible facial cancer spread by direct transfer of living cancer …

The structure of the contact network between individuals has a profound effect on the
transmission of infectious disease. Using a novel technology–proximity sensing radio collars …

Contagious cancers that pass between individuals as an infectious cell line are highly
unusual pathogens. Devil facial tumor disease (DFTD) is one such contagious cancer that …

The Tasmanian devil (Sarcophilus harrisii) is threatened with extinction because of a
contagious cancer known as Devil Facial Tumor Disease. The inability to mount an immune …