Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune …

S Magez, JE Pinto Torres, E Obishakin… - Frontiers in …, 2020 - frontiersin.org
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game
animals around the world. Through co-evolution with the mammalian immune system …

Trypanosomes and complement: more than one way to die?

AD Cook, M Carrington, MK Higgins - Trends in Parasitology, 2023 - cell.com
African trypanosomes show a remarkable ability to survive as extracellular parasites in the
blood and tissue spaces of an infected mammal. Throughout the infection they are exposed …

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

OJS Macleod, AD Cook, H Webb, M Crow… - Nature …, 2022 - nature.com
African trypanosomes are extracellular pathogens of mammals and are exposed to the
adaptive and innate immune systems. Trypanosomes evade the adaptive immune response …

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic …

HTT Nguyen, RB Guevarra, S Magez… - PLoS …, 2021 - journals.plos.org
Salivarian trypanosomes are extracellular protozoan parasites causing infections in a wide
range of mammalian hosts, with Trypanosoma evansi having the widest geographic …

T cells and immunopathogenesis of experimental African trypanosomiasis

H Tabel, G Wei, M Shi - Immunological reviews, 2008 - Wiley Online Library
African trypanosomes are pathogens for humans and livestock. They are single‐cell, extra‐
cellular parasites that cause persistent infections of the blood and induce profound …

Cytokines and antibody responses during Trypanosoma congolense infections in two inbred mouse strains that differ in resistance

JE Uzonna, RS Kaushik, JR Gordon… - Parasite …, 1999 - Wiley Online Library
We studied IL‐4, IL‐10 and IFN‐γ secretion by splenocytes and the plasma levels of different
isotypes of antibodies against various antigens of Trypanosoma congolense in highly …

[HTML][HTML] CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent …

W Pan, O Ogunremi, G Wei, M Shi, H Tabel - Microbes and Infection, 2006 - Elsevier
Immunoglobulin M (IgM) antibodies to the variant surface glycoproteins (VSG) of African
trypanosomes are the first and predominant class of anti-trypanosomal antibodies in the …

Immunosuppression: cause for failures of vaccines against African trypanosomiases

H Tabel, G Wei, HJ Bull - PLoS neglected tropical diseases, 2013 - journals.plos.org
Antibodies to the variant surface glycoprotein (VSG) are required for the control of African
trypanosomes infecting the blood, whereas infections of the skin by low numbers of …

[HTML][HTML] Susceptibility and resistance to Trypanosoma congolense infections

H Tabel, RS Kaushik, JE Uzonna - Microbes and Infection, 2000 - Elsevier
We have put emphasis on recent findings in experimental Trypanosoma congolense
infections in highly susceptible BALB/c and relatively resistant C57Bl/6 mice. Based on …

African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory So That Post-Treatment Bordetella pertussis Challenge Fails to Trigger a Protective …

M Radwanska, HTT Nguyen, S Magez - Vaccines, 2021 - mdpi.com
Salivarian trypanosomes are extracellular parasites causing anthroponotic and zoonotic
infections. Anti-parasite vaccination is considered the only sustainable method for global …