The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but
because only a percentage of patients are responsive to immunotherapy, it is imperative to …

Analysis of gene expression data is widely used in transcriptomic studies to understand
functions of molecules inside a cell and interactions among molecules. Differential co …

Premature termination codon (PTC)-bearing transcripts are often degraded by nonsense-
mediated decay (NMD) resulting in loss-of-function (LoF) alleles. However, not all PTCs …

Previous studies reported that Angiotensin converting enzyme 2 (ACE2) is the main cell
receptor of SARS-CoV and SARS-CoV-2. It plays a key role in the access of the virus into the …

Epilepsy includes a group of disorders of the brain characterized by an enduring
predisposition to generate epileptic seizures. Although familial epilepsy has a genetic …

MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential
epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously …

Technologies for profiling samples using different omics platforms have been at the forefront
since the human genome project. Large-scale multi-omics data hold the promise of …

Objective Short-term intensive insulin therapy (IIT) early in the course of type 2 diabetes
acutely improves beta-cell function with long-lasting effects on glycemic control. However …

Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic
events such as invasion, metabolic reprogramming, epithelial–mesenchymal transition …

Background Interaction between malignant cells and immune cells that reside within the
tumor microenvironment (TME) modulate different aspects of tumor development and …