TetR family regulators (TFRs) represent a large group of one-component bacterial signal
transduction systems which recognize environmental signals, like the presence of antibiotics …

Actinobacteria are a large and diverse group of bacteria that are known to produce a wide
range of secondary metabolites, many of which have important biological activities …

Predicting the protein–nucleic acid (PNA) binding affinity solely from their sequences is of
paramount importance for the experimental design and analysis of PNA interactions …

Antibiotics usually induce the hormetic effects on bacteria, featured by low-dose stimulation
and high-dose inhibition, which challenges the central belief in toxicity assessment and …

Bacteria produce natural products (NPs) via biosynthetic gene clusters. Unfortunately, many
biosynthetic gene clusters are silent under traditional laboratory conditions. To access novel …

Streptomyces species are intensively studied for their ability to produce a variety of natural
products. However, conditions influencing and leading to product formation are often not …

Polyketides are one of the largest categories of secondary metabolites, and their
biosynthesis is initiated by polyketide synthases (PKSs) using coenzyme A esters of short …

Actinobacteria produce a plethora of bioactive secondary metabolites that are often
regulated by quorum-sensing signaling molecules via specific binding to their cognate TetR …

The production of secondary metabolites is a major mechanism used by beneficial
rhizobacteria to antagonize plant pathogens. These bacteria have evolved to coordinate the …

The TetR family of regulators (TFRs), commonly reported as repressors, plays a role in
regulating secondary metabolite production in Streptomyces. In this study, we sought to …