Since the initial report of Oguni and Omi on the reaction of diethylzinc with benzaldehyde in
the presence of a catalytic amount of (S)-leucinol with moderate enantioselectivity (49% ee) …

One of the initial steps in the development of therapeutic agents is the identification of lead
compounds that bind to the receptor or enzyme target of interest. Many analogs of these …

During the last six years, combinatorial chemistry has attracted enormous attention from the
pharmaceutical industry because it can greatly facilitate the drug discovery process. 1 At the …

Interest in green chemistry and clean processes has grown so much in recent years that
topics such as fluorous biphasic catalysis, metal organic frameworks, and process …

New organic reactivity has often been discovered by happenstance. Several recent research
efforts have attempted to leverage this to discover new reactions. In this Review, we attempt …

Nach dem Paradigmenwechsel, der in der pharmazeutischen Industrie stattfand, als durch
kombinatorische Methoden der Prozeß zur Entdeckung neuer Wirkstoffe unwiderruflich …

Innerhalb weniger Jahre hat sich die kombinatorische Synthese von einer Laborkuriosität zu
einer ernstzunehmenden Methode in der Wirkstofforschung entwickelt. Die rasanten …

Abstract Kombinatorische Methoden in der Entwicklung enantioselektiver homogener
Katalysatoren stellen einen neuen Zweig der Katalyseforschung dar. Ziel ist es, Bibliotheken …

Combinatorial methods in the development of enantioselective homogeneous catalysts
constitute a new branch of catalysis research. The goal is to prepare libraries of potential …

After forever changing the drug discovery process in the pharmaceutical industry,
combinatorial chemistry methodologies are increasingly being applied to the discovery and …