Since the initial report of Oguni and Omi on the reaction of diethylzinc with benzaldehyde in
the presence of a catalytic amount of (S)-leucinol with moderate enantioselectivity (49% ee) …

During the last six years, combinatorial chemistry has attracted enormous attention from the
pharmaceutical industry because it can greatly facilitate the drug discovery process. 1 At the …

One of the initial steps in the development of therapeutic agents is the identification of lead
compounds that bind to the receptor or enzyme target of interest. Many analogs of these …

Interest in green chemistry and clean processes has grown so much in recent years that
topics such as fluorous biphasic catalysis, metal organic frameworks, and process …

New organic reactivity has often been discovered by happenstance. Several recent research
efforts have attempted to leverage this to discover new reactions. In this Review, we attempt …

Combinatorial methods in the development of enantioselective homogeneous catalysts
constitute a new branch of catalysis research. The goal is to prepare libraries of potential …

After forever changing the drug discovery process in the pharmaceutical industry,
combinatorial chemistry methodologies are increasingly being applied to the discovery and …

Combinatorial synthesis has developed within a few years from a laboratory curiosity to a
method that is taken seriously in drug research. Rapid progress in molecular biology and the …

About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or
prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly …

A new fluorescence-based assay for high-throughput screening of reactions that couple two
organic molecules is described. The assay involves reaction of one substrate containing a …