Alopecia areata (AA) is an autoimmune disease of the hair follicles. It is characterized by a
well-defined non-scarring alopecic patch or patches that may extend to the entire scalp or …

Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …

Caused by the loss in the tolerance against self‐antigens, autoimmune diseases are chronic
disorders that impact millions of individuals annually with significant economic burden. They …

Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

T lymphocytes encounter complex mechanical cues during an immune response. The
mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial …

Multiple sclerosis (MS) is an autoimmune disorder causing demyelination and
neurodegeneration in the central nervous system. MS is characterized by disturbed motor …

Antiviral immunity often requires CD8+ cytotoxic T lymphocytes (CTLs) that actively migrate
and search for virus-infected targets. Regulatory T cells (Tregs) have been shown to …

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with
Alzheimer’s disease | Translational Neurodegeneration Skip to main content SpringerLink …

Abstract The T-helper 17 (Th17) cell and regulatory T cell (Treg) axis plays a crucial role in
the development of multiple sclerosis (MS), which is regarded as an immune imbalance …

Brain antigen-specific autoreactive T cells seem to play a key role in inducing inflammation
in the central nervous system (CNS), a characteristic feature of human multiple sclerosis …