Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
[HTML][HTML] Navigating the DNA methylation landscape of cancer
A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …
control of gene expression and genome stability. Disruption of DNA methylation control …
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
Abstract DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …
The 5-hydroxymethylcytosine landscape of prostate cancer
M Sjöström, SG Zhao, S Levy, M Zhang, Y Ning… - Cancer research, 2022 - AACR
Abstract Analysis of DNA methylation is a valuable tool to understand disease progression
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …
LncRNAs and the cancer epigenome: Mechanisms and therapeutic potential
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome,
modulating gene expression through DNA methylation, histone modification, and/or …
modulating gene expression through DNA methylation, histone modification, and/or …
[HTML][HTML] Current advances in detecting genetic and epigenetic biomarkers of colorectal cancer
Colorectal carcinoma (CRC) is the third most common cancer in terms of diagnosis and the
second in terms of mortality. Recent studies have shown that various proteins, extracellular …
second in terms of mortality. Recent studies have shown that various proteins, extracellular …
DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 monomethylation patterns
Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion
are subject to hypermethylation. Using methylome sequencing we identified CpG islands …
are subject to hypermethylation. Using methylome sequencing we identified CpG islands …
Bisulfite-free and single-nucleotide resolution sequencing of DNA epigenetic modification of 5-hydroxymethylcytosine using engineered deaminase
NB **e, M Wang, TT Ji, X Guo, JH Ding, BF Yuan… - Chemical …, 2022 - pubs.rsc.org
The discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes is a landmark in
epigenomics study. Similar to 5-methylcytosine (5mC), 5hmC is viewed as a critical …
epigenomics study. Similar to 5-methylcytosine (5mC), 5hmC is viewed as a critical …