APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
Initiation and propagation of α-synuclein aggregation in the nervous system
The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …
LRP1 is a master regulator of tau uptake and spread
The spread of protein aggregates during disease progression is a common theme
underlying many neurodegenerative diseases. The microtubule-associated protein tau has …
underlying many neurodegenerative diseases. The microtubule-associated protein tau has …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
Y Atagi, CC Liu, MM Painter, XF Chen… - Journal of Biological …, 2015 - ASBMB
Several heterozygous missense mutations in the triggering receptor expressed on myeloid
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread
A recent case report described an individual who was a homozygous carrier of the APOE3
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …
Apolipoprotein E, receptors, and modulation of Alzheimer's disease
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
Recent experimental evidence suggests that transcellular propagation of fibrillar protein
aggregates drives the progression of neurodegenerative diseases in a prion-like manner …
aggregates drives the progression of neurodegenerative diseases in a prion-like manner …
ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of
Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also …
Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also …
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
Apolipoprotein E gene (APOE) alleles may shift the onset of Alzheimer's disease (AD)
through apoE protein isoforms changing the probability of amyloid-β (Aβ) accumulation. It …
through apoE protein isoforms changing the probability of amyloid-β (Aβ) accumulation. It …