Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Inflammation contributes to the pathogenesis of most acute and chronic liver diseases.
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …

Given the high prevalence and rising incidence of non-alcoholic fatty liver disease (NAFLD),
the absence of approved therapies is striking. Although the mainstay of treatment of NAFLD …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Fibrosis, which leads to progressive loss of tissue function and eventual organ failure, has
been estimated to contribute to~ 45% of deaths in the developed world, and so new …

Abstract Background & Aims Hepatocyte apoptosis, the hallmark of non‐alcoholic
steatohepatitis (NASH) contributes to liver injury and fibrosis. Although, both the intrinsic and …

Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures,
ligament or meniscus tears and damage to the articular cartilage. This is often associated …

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of
increasing significance due to increased use of expanded criteria livers for transplantation …

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an
inflammatory phenotype. This process contributes profoundly to the pathophysiology of …