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Cell-derived nanovesicle-mediated drug delivery to the brain: principles and strategies for vesicle engineering
Y Liang, Z Iqbal, J Lu, J Wang, H Zhang, X Chen… - Molecular Therapy, 2023 - cell.com
Develo** strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …
Repetitive restricted behaviors in autism spectrum disorder: From mechanism to development of therapeutics
J Tian, X Gao, L Yang - Frontiers in Neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by deficits in social communication, social interaction, and repetitive restricted behaviors …
by deficits in social communication, social interaction, and repetitive restricted behaviors …
Stimulating extracellular vesicles production from engineered tissues by mechanical forces
Extracellular vesicles (EVs) have emerged as a promising strategy to promote tissue
regeneration. However, overcoming the low EV production yield remains a big challenge in …
regeneration. However, overcoming the low EV production yield remains a big challenge in …
Intranasal delivery of functionalized polymeric nanomaterials to the brain
Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for
treating neurological disorders is often constrained by low delivery efficacy due to difficulties …
treating neurological disorders is often constrained by low delivery efficacy due to difficulties …
Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …
Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine
Tissue-specific uptake and sufficient biodistribution are central goals in drug development.
Crossing the blood–brain barrier (BBB) represents a major challenge in delivering …
Crossing the blood–brain barrier (BBB) represents a major challenge in delivering …
[HTML][HTML] Blood exosome sensing via neuronal insulin-like growth factor-1 regulates autism-related phenotypes
L Chen, XY **ong, TT Yao, LN Gui, F Luo, Y Du… - Pharmacological …, 2023 - Elsevier
The development and progression of autism spectrum disorder (ASD) is characterized by
multiple complex molecular events, highlighting the importance of the prefrontal brain …
multiple complex molecular events, highlighting the importance of the prefrontal brain …
Extracellular vesicles in mental disorders: a state-of-art review
L Kong, D Zhang, S Huang, J Lai, L Lu… - … journal of biological …, 2023 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are nanoscale particles with various physiological functions
including mediating cellular communication in the central nervous system (CNS), which …
including mediating cellular communication in the central nervous system (CNS), which …
[HTML][HTML] Mechanisms and biomarker potential of extracellular vesicles in stroke
Simple Summary A stroke occurs when there is a lack of blood flow to the brain. Stroke
injures the brain and can have devastating outcomes depending on the size and location of …
injures the brain and can have devastating outcomes depending on the size and location of …
Function of exosomes in neurological disorders and brain tumors
Exosomes are a subtype of extracellular vesicles released from different cell types including
those in the nervous system, and are enriched in a variety of bioactive molecules such as …
those in the nervous system, and are enriched in a variety of bioactive molecules such as …