Cell-derived nanovesicle-mediated drug delivery to the brain: principles and strategies for vesicle engineering

Y Liang, Z Iqbal, J Lu, J Wang, H Zhang, X Chen… - Molecular Therapy, 2023 - cell.com
Develo** strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

Repetitive restricted behaviors in autism spectrum disorder: From mechanism to development of therapeutics

J Tian, X Gao, L Yang - Frontiers in Neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by deficits in social communication, social interaction, and repetitive restricted behaviors …

Stimulating extracellular vesicles production from engineered tissues by mechanical forces

S Guo, L Debbi, B Zohar, R Samuel, RS Arzi… - Nano Letters, 2021 - ACS Publications
Extracellular vesicles (EVs) have emerged as a promising strategy to promote tissue
regeneration. However, overcoming the low EV production yield remains a big challenge in …

Intranasal delivery of functionalized polymeric nanomaterials to the brain

S Zha, KL Wong, AH All - Advanced Healthcare Materials, 2022 - Wiley Online Library
Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for
treating neurological disorders is often constrained by low delivery efficacy due to difficulties …

Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases

S Herman, I Fishel, D Offen - Stem Cells, 2021 - academic.oup.com
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …

Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine

N Yom-Tov, R Guy, D Offen - Advanced Drug Delivery Reviews, 2022 - Elsevier
Tissue-specific uptake and sufficient biodistribution are central goals in drug development.
Crossing the blood–brain barrier (BBB) represents a major challenge in delivering …

[HTML][HTML] Blood exosome sensing via neuronal insulin-like growth factor-1 regulates autism-related phenotypes

L Chen, XY **ong, TT Yao, LN Gui, F Luo, Y Du… - Pharmacological …, 2023 - Elsevier
The development and progression of autism spectrum disorder (ASD) is characterized by
multiple complex molecular events, highlighting the importance of the prefrontal brain …

Extracellular vesicles in mental disorders: a state-of-art review

L Kong, D Zhang, S Huang, J Lai, L Lu… - … journal of biological …, 2023 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are nanoscale particles with various physiological functions
including mediating cellular communication in the central nervous system (CNS), which …

[HTML][HTML] Mechanisms and biomarker potential of extracellular vesicles in stroke

N Ollen-Bittle, AD Roseborough, W Wang, JD Wu… - Biology, 2022 - mdpi.com
Simple Summary A stroke occurs when there is a lack of blood flow to the brain. Stroke
injures the brain and can have devastating outcomes depending on the size and location of …

Function of exosomes in neurological disorders and brain tumors

L **ao, S Hareendran, YP Loh - Extracellular vesicles and …, 2021 - pmc.ncbi.nlm.nih.gov
Exosomes are a subtype of extracellular vesicles released from different cell types including
those in the nervous system, and are enriched in a variety of bioactive molecules such as …