Deep multiple instance learning on heterogeneous graph for drug–disease association prediction

Y Gu, S Zheng, B Zhang, H Kang, R Jiang… - Computers in Biology and …, 2025 - Elsevier
Drug repositioning offers promising prospects for accelerating drug discovery by identifying
potential drug–disease associations (DDAs) for existing drugs and diseases. Previous …

[HTML][HTML] MGACL: Prediction Drug–Protein Interaction Based on Meta-Graph Association-Aware Contrastive Learning

P Zhang, P Lin, D Li, W Wang, X Qi, J Li, J **ong - Biomolecules, 2024 - mdpi.com
The identification of drug–target interaction (DTI) is crucial for drug discovery. However, how
to reduce the graph neural network's false positives due to its bias and negative transfer in …

OSGAN: Omni-scale and Global-aware ECG arrhythmia diagnostic network

C Chen, B **, C Che, R Li - Biomedical Signal Processing and Control, 2024 - Elsevier
Automated arrhythmia detection using electrocardiogram (ECG) signals is critical for
cardiovascular disease prevention and treatment. However, the widely used CNN-based …

Drug repositioning based on tripartite cross-network embedding and graph convolutional network

P Zeng, B Zhang, A Liu, Y Meng, X Tang, J Yang… - Expert Systems with …, 2024 - Elsevier
Drug-disease association prediction is an important part of drug discovery, which can help
researchers uncover potential drug candidates and disease targets more accurately to deal …

SGCLDGA: unveiling drug–gene associations through simple graph contrastive learning

Y Fan, C Zhang, X Hu, Z Huang, J Xue… - Briefings in …, 2024 - academic.oup.com
Drug repurposing offers a viable strategy for discovering new drugs and therapeutic targets
through the analysis of drug–gene interactions. However, traditional experimental methods …

SDDSynergy: Learning Important Molecular Substructures for Explainable Anticancer Drug Synergy Prediction

Y Liu, P Zhang, C Che, Z Wei - Journal of Chemical Information …, 2024 - ACS Publications
Drug combination therapies are well-established strategies for the treatment of cancer with
low toxicity and fewer adverse effects. Computational drug synergy prediction approaches …

AGCLNDA: Enhancing the Prediction of ncRNA-Drug Resistance Association Using Adaptive Graph Contrastive Learning

Y Fan, C Zhang, X Hu, Z Huang… - IEEE Journal of …, 2025 - ieeexplore.ieee.org
Non-coding RNAs (ncRNAs), which do not encode proteins, have been implicated in
chemotherapy resistance in cancer treatment. Given the high costs and time requirements of …

Boosting drug-disease association prediction for drug repositioning via dual-feature extraction and cross-dual-domain decoding

E Zhu, X Li, C Liu, NR Pal - arxiv preprint arxiv:2407.11812, 2024 - arxiv.org
The extraction of biomedical data has significant academic and practical value in
contemporary biomedical sciences. In recent years, drug repositioning, a cost-effective …

Key Substructure Learning with Chemical Intuition for Material Property Prediction

P Zhang, J Yuan, L Li, W Luo, J Hu, X Li - International Conference on …, 2024 - Springer
Substructures are crucial factors influencing material molecular properties, and the effective
identification of molecular substructures can accelerate novel material discovery. The …

Antibiotic Bacteria Interaction: Dataset and Benchmarking.

S Chatterjee, A Majumdar, E Chouzenoux - bioRxiv, 2024 - biorxiv.org
This study introduces a dataset for drug-bacteria associations (DBA) that affects humans.
Our contribution extends beyond merely curating the association matrix; we also conduct …