Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Epstein–Barr virus in multiple sclerosis: theory and emerging immunotherapies

A Bar-Or, MP Pender, R Khanna, L Steinman… - Trends in molecular …, 2020 - cell.com
New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Comprehensive investigations relationship between viral infections and multiple sclerosis pathogenesis

S Sedighi, O Gholizadeh, S Yasamineh… - Current …, 2023 - Springer
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous
system (CNS). Compared to other types of self-limiting myelin disorders, MS …

The role of Epstein-Barr virus in the etiology of multiple sclerosis: a current review

K Ruprecht - Expert review of clinical immunology, 2020 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the
central nervous system. While its exact etiology is unknown, it is generally believed that MS …

[HTML][HTML] Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases

L Bogers, KL Kuiper, J Smolders, J Rip, MM van Luijn - Immunology letters, 2023 - Elsevier
B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …

The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunities

A Afrasiabi, C Ahlenstiel… - Clinical & …, 2023 - Wiley Online Library
Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease, characterised
by the demyelination of neurons in the central nervous system. Whilst it is unclear what …

The Interaction of Human and Epstein–Barr Virus miRNAs with Multiple Sclerosis Risk Loci

A Afrasiabi, NL Fewings, SD Schibeci… - International Journal of …, 2021 - mdpi.com
Although the causes of Multiple Sclerosis (MS) still remain largely unknown, multiple lines of
evidence suggest that Epstein–Barr virus (EBV) infection may contribute to the development …

The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases

AH Borghol, ER Bitar, A Hanna, G Naim… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract Epstein-Barr Virus (EBV), a dsDNA herpesvirus, is believed to play a significant role
in exacerbating and potentially triggering autoimmune and autoinflammatory maladies …

[HTML][HTML] Genetic and transcriptomic analyses support a switch to lytic phase in Epstein Barr virus infection as an important driver in develo** Systemic Lupus …

A Afrasiabi, JT Keane, LTC Ong, H Alinejad-Rokny… - Journal of …, 2022 - Elsevier
To investigate the molecular mechanisms through which Epstein-Barr virus (EBV) may
contribute to Systemic Lupus Erythematosus (SLE) pathogenesis, we interrogated SLE …