Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …

In this paper, we describe the use of iTRAQ (isobaric Tags for Relative and Absolute
Quantitation) tags for comparison of protein expression levels between multiple samples …

A urine sample preparation workflow for the iTRAQ (isobaric tag for relative and absolute
quantitation) technique was established. The reproducibility of this platform was evaluated …

Multiple, complex molecular events characterize cancer development and progression.
Deciphering the molecular networks that distinguish organ-confined disease from metastatic …

The clinical and fundamental research in prostate cancer-the most common urological
cancer in men-is currently entering the proteomic and genomic era. The focus has switched …

The present pilot study constitutes a proof-of-principle in the use of a quantitative LC-MS/MS
based proteomic method for the comparative analysis of representative low-grade breast …

The combination of liquid chromatography and mass spectrometry (LC–MS) is a powerful
and indispensable analytical tool that is widely applied in many areas of chemistry …

The concept of tissues appeared more than 200 years ago, since textures and attendant
differences were described within the whole organism components. Instrumental …

Multidimensional chromatography coupled to mass spectrometry (LCn‐MS) provides more
separation power and an extended measured dynamic concentration range to analyse …