Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …

The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human
cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate
lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

Cancer cells simultaneously harbor global losses and gains in DNA methylation. We
demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits …