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Novel therapeutic targets for cholestatic and fatty liver disease
M Trauner, CD Fuchs - Gut, 2022 - gut.bmj.com
Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …
both in development and in pathological conditions. Here, we review the literature about the …
EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis
Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver
disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is …
disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is …
A placebo-controlled trial of obeticholic acid in primary biliary cholangitis
Background Primary biliary cholangitis (formerly called primary biliary cirrhosis) can
progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin …
progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin …
Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial
Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and
increased serum bile acid concentrations, is associated with increased rates of stillbirth …
increased serum bile acid concentrations, is associated with increased rates of stillbirth …
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
The primary sensory system requires the integrated function of multiple cell types, although
its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 …
its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 …
Peripheral and central mechanisms of itch
Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …
Itch: from mechanism to (novel) therapeutic approaches
Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …
diseases, as well as in those with systemic and neuropathic conditions. In patients with …
Mechanisms of pruritus in cholestasis: understanding and treating the itch
Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the
quality of life of those affected. Here, we provide an update on the latest insights into the …
quality of life of those affected. Here, we provide an update on the latest insights into the …
The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines
Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …