Primary open-angle glaucoma
RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications
T McLaughlin, A Medina, J Perkins, M Yera… - Molecular …, 2022 - Springer
Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …
self-reparation and regeneration in mammals, is under cumulative environmental stress due …
Primary open-angle glaucoma preferred practice pattern®
SJ Gedde, K Vinod, MM Wright, KW Muir, JT Lind… - Ophthalmology, 2021 - Elsevier
Background Primary open angle glaucoma (POAG) is a chronic, progressive ocular disease
causing loss of the optic nerve rim and retinal nerve fiber layer (RNFL) with associated …
causing loss of the optic nerve rim and retinal nerve fiber layer (RNFL) with associated …
[PDF][PDF] Primary open-angle glaucoma preferred practice pattern® guidelines
Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy in adults
in which there is a characteristic acquired atrophy of the optic nerve and loss of retinal …
in which there is a characteristic acquired atrophy of the optic nerve and loss of retinal …
An ER translocon for multi-pass membrane protein biogenesis
Membrane proteins with multiple transmembrane domains play critical roles in cell
physiology, but little is known about the machinery coordinating their biogenesis at the …
physiology, but little is known about the machinery coordinating their biogenesis at the …
[HTML][HTML] Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer
Many regions in the human genome vary in length among individuals due to variable
numbers of tandem repeats (VNTRs). To assess the phenotypic impact of VNTRs genome …
numbers of tandem repeats (VNTRs). To assess the phenotypic impact of VNTRs genome …
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To
identify new susceptibility loci, we performed meta-analysis on genome-wide association …
identify new susceptibility loci, we performed meta-analysis on genome-wide association …
Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
A Congrains, K Kamide, R Oguro, O Yasuda, K Miyata… - Atherosclerosis, 2012 - Elsevier
Genome-wide association studies (GWAS) have identified genetic variants contributing to
the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD …
the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD …
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Central corneal thickness (CCT) is associated with eye conditions including keratoconus
and glaucoma. We performed a meta-analysis on> 20,000 individuals in European and …
and glaucoma. We performed a meta-analysis on> 20,000 individuals in European and …
Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …