Platelets are most often recognized for their crucial role in the control of acute hemorrhage.
However, current research has greatly expanded the appreciation of platelets beyond their …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Platelet aggregation, the process by which platelets adhere to each other at sites of vascular
injury, has long been recognized as critical for hemostatic plug formation and thrombosis …

The liver can regenerate its volume after major tissue loss. In a mouse model of liver
regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate …

Platelets are essential for primary hemostasis, but they also play an important pro-
inflammatory role. Platelets normally circulate in a quiescent state. Upon activation, platelets …

Platelets are specialized blood cells that play central roles in physiologic and pathologic
processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense …

Platelet activation occurs in response to vessel injury and is important for the arrest of
bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic …

Cardiovascular disease, particularly coronary artery dis-ease resulting from accelerated
atherosclerosis, is the leading cause of morbidity and mortality in patients with diabetes …

The accumulation of thrombin at sites of vascular injury provides one of the chief means for
recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years …

YM-254890, which was isolated from the culture broth of Chromobacterium sp., inhibits ADP-
induced platelet aggregation and has antithrombotic and thrombolytic effects. YM-254890 …