Innate lymphoid cells in intestinal inflammation
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that
encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but …
encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but …
[HTML][HTML] GATA-3 function in innate and adaptive immunity
The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …
Directing traffic: IL‐17 and IL‐22 coordinate pulmonary immune defense
Respiratory infections and diseases are among the leading causes of death worldwide, and
effective treatments probably require manipulating the inflammatory response to pathogenic …
effective treatments probably require manipulating the inflammatory response to pathogenic …
Barriers to inhaled gene therapy of obstructive lung diseases: A review
Abstract Knowledge of genetic origins of obstructive lung diseases has made inhaled gene
therapy an attractive alternative to the current standards of care that are limited to managing …
therapy an attractive alternative to the current standards of care that are limited to managing …
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Innate lymphoid cells (ILCs) are well-characterized immune cells that play key roles in host
defense and tissue homeostasis. Yet, how the three-dimensional (3D) genome organization …
defense and tissue homeostasis. Yet, how the three-dimensional (3D) genome organization …
Profiles of lamina propria T helper cell subsets discriminate between ulcerative colitis and Crohn's disease
J Li, A Ueno, M Fort Gasia, J Luider… - Inflammatory bowel …, 2016 - academic.oup.com
Background Distinction between 2 forms of inflammatory bowel disease (IBD), ulcerative
colitis (UC) and Crohn's disease (CD), can be challenging. Aberrant mucosal immunity …
colitis (UC) and Crohn's disease (CD), can be challenging. Aberrant mucosal immunity …
Animal model of asthma, various methods and measured parameters: a methodological review
Asthma is a chronic inflammatory disease of the airway with extensive airway remodeling.
The ethical issues associated with the studies in asthmatic patients, required development of …
The ethical issues associated with the studies in asthmatic patients, required development of …
Type 2 innate lymphoid cells: at the cross-roads in allergic asthma
L van Rijt, H von Richthofen, R van Ree - Seminars in immunopathology, 2016 - Springer
Allergic asthma is a chronic inflammatory disease of the lower airways that affects millions of
people worldwide. Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 …
people worldwide. Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 …
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse …
J Xu, J Guardado, R Hoffman, H Xu, R Namas… - PLoS …, 2017 - journals.plos.org
Background The immunosuppression and immune dysregulation that follows severe injury
includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and …
includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and …
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa
A Laulajainen-Hongisto, A Lyly, T Hanif… - Clinical and translational …, 2020 - Springer
Genome wide association studies (GWASs) have revealed several airway disease-
associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic …
associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic …