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The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions
The hypothalamic-pituitary-adrenal axis is a complex system of neuroendocrine pathways
and feedback loops that function to maintain physiological homeostasis. Abnormal …
and feedback loops that function to maintain physiological homeostasis. Abnormal …
Filling the gap: neural stem cells as a promising therapy for spinal cord injury
Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …
Map** the ethical issues of brain organoid research and application
In 2008, researchers created human three-dimensional neural tissue–known as the
pioneering work of “brain organoids.” In recent years, some researchers have transplanted …
pioneering work of “brain organoids.” In recent years, some researchers have transplanted …
The ethics of cerebral organoid research: being conscious of consciousness
T Sawai, H Sakaguchi, E Thomas, J Takahashi… - Stem Cell Reports, 2019 - cell.com
Recently, the use of three-dimensional neural tissues cultured in vitro and called" cerebral
organoids" has advanced recapitulation of neural development and disease modeling …
organoids" has advanced recapitulation of neural development and disease modeling …
Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition
During neural tube (NT) development, the notochord induces an organizer, the floorplate,
which secretes Sonic Hedgehog (SHH) to pattern neural progenitors. Conversely, NT …
which secretes Sonic Hedgehog (SHH) to pattern neural progenitors. Conversely, NT …
Engineering multiscale structural orders for high-fidelity embryoids and organoids
Embryoids and organoids hold great promise for human biology and medicine. Herein, we
discuss conceptual and technological frameworks useful for develo** high-fidelity …
discuss conceptual and technological frameworks useful for develo** high-fidelity …
Neural lineage differentiation from pluripotent stem cells to mimic human brain tissues
Recent advances in induced pluripotent stem cell (iPSC) research have turned limitations of
prior and current research into possibilities. iPSCs can differentiate into the desired cell …
prior and current research into possibilities. iPSCs can differentiate into the desired cell …
[HTML][HTML] Mouse vs man: Organoid models of brain development & disease
Brain organoids have rapidly become established as promising tools for studying both the
normal embryonic development of the brain and the mechanistic roots of …
normal embryonic development of the brain and the mechanistic roots of …
[HTML][HTML] Cerebral organoids as an experimental platform for human neurogenomics
The cerebral cortex forms early in development according to a series of heritable
neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral …
neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral …
Human brain development through the lens of cerebral organoid models
The brain is one of the most complex organs in the body, which emerges from a relatively
simple set of basic 'building blocks' during early development according to complex cellular …
simple set of basic 'building blocks' during early development according to complex cellular …