Fentanyl is a synthetic, highly selective opioid with many desirable physicochemical
properties, including a high lipophilicity and predictable pharmacokinetics. These properties …

Background: The delivery of drugs through the buccal mucosa has received a great deal of
attention over the last two decades, and yet there are not many buccal delivery products …

Erfahren Sie alles über Opioide, was Sie schon immer wissen wollten:-Physiologie des
Schmerzgeschehens,-Wirkungsweise, Nebenwirkungen von Opioiden,-Indikationen und …

Introduction: There have been several advances in the delivery of drugs through the buccal
mucosa over the last 5 years, which have resulted in a number of new buccal delivery …

Breakthrough pain (BTP) is a transitory pain (reaching maximum severity in∼ 15 minutes
and lasting∼ 60 minutes in patients with cancer) that occurs despite the management of …

Breakthrough pain is a transient exacerbation of pain that occurs either spontaneously or in
relation to a specific predictable or unpredictable trigger, despite relatively stable and …

With contributions from recognized authorities in industry, academia, and government, this
reference presents the state-of-the-art in the testing, formulation, and clinical evaluation of …

Noninvasive opioid delivery systems that provide rapid pain relief offer advantages for
outpatients with high-intensity, rapid-onset pain. fentanyl effervescent buccal tablets (FEBT) …

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Background: The fentanyl effervescent buccal tablet (FEBT) was designed to enhance the
rate and extent of absorption of fentanyl through the buccal mucosa. FEBT is being …