Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Mitochondrial creatine kinase (MtCK), together with cytosolic creatine kinase isoenzymes
and the highly diffusible CK reaction product, phosphocreatine, provide a temporal and …

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free
radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic …

Metformin is used for the treatment of insulin resistant diabetes. Diabetics are at an
increased risk of develo** dementia. Recent epidemiological studies suggest that …

Obesity is associated with cognitive impairments. Long-term mechanisms for this association
include consequences of hyperglycemia, dyslipidemia, or other factors comprising metabolic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
pathologically by the presence of senile plaques, neurofibrillary tangles, and synapse loss …

The initiation and progression of Alzheimer disease (AD) is a complex process not yet fully
understood. While many hypotheses have been provided as to the cause of the disease, the …

Alzheimer's disease (AD) brains are characterized by accumulation of amyloid β protein (Aβ)
and neuroinflammation. Increased blood-to-brain influx and decreased brain-to-blood efflux …

The senescence-accelerated mouse (SAM) is an accelerated aging model that was
established through phenotypic selection from a common genetic pool of AKR/J strain of …

Mild cognitive impairment (MCI) is generally referred to the transitional zone between
normal cognitive function and early dementia or clinically probable Alzheimer's disease …