Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with …

A Arjunan, DK Sah, M Woo, J Song - Cell & Bioscience, 2023‏ - Springer
Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis

R Peters, A Booth, K Rockwood, J Peters, C D'Este… - BMJ open, 2019‏ - bmjopen.bmj.com
Objective To systematically review the literature relating to the impact of multiple co-
occurring modifiable risk factors for cognitive decline and dementia. Design A systematic …

Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment

X Li, D Song, SX Leng - Clinical interventions in aging, 2015‏ - Taylor & Francis
The aim of this paper is to provide a comprehensive review of the epidemiological evidence
linking type 2 diabetes mellitus and its related conditions, including obesity …

Metabolic syndrome and cognitive decline in the elderly: a systematic review

N Assuncao, FK Sudo, C Drummond, FG de Felice… - PloS one, 2018‏ - journals.plos.org
Background Metabolic Syndrome (MetS) refers to a cluster of metabolic disturbances which
is associated with increased risk for vascular and degenerative conditions in general …

Metabolic syndrome and longitudinal changes in cognitive function: a systematic review and meta-analysis

M Siervo, SL Harrison, C Jagger… - Journal of …, 2014‏ - content.iospress.com
Background: Metabolic syndrome (MetS) is associated with an increased risk of coronary
heart diseases and stroke. Results on the association of MetS with dementia and cognitive …

Metabolic syndrome and the risk of late onset Alzheimer's disease: An updated review and meta-analysis

M Zuin, L Roncon, A Passaro, C Cervellati… - Nutrition, Metabolism and …, 2021‏ - Elsevier
Aims This study aims to provide an updated systematic review and meta-analysis on the risk
of Alzheimer's disease (AD) in patients with metabolic syndrome (MetS) and to analyze the …

Insulin resistance: a connecting link between Alzheimer's disease and metabolic disorder

V Kshirsagar, C Thingore, A Juvekar - Metabolic Brain Disease, 2021‏ - Springer
Recent evidence suggests that Alzheimer's disease (AD) is closely linked with insulin
resistance, as seen in type 2 diabetes mellitus (T2DM). Insulin signaling is impaired in AD …

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

JA Rios, P Cisternas, M Arrese, S Barja… - Progress in …, 2014‏ - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 36
million people worldwide. AD is characterized by a progressive loss of cognitive functions …

The factor structure of cognitive functioning in cognitively healthy participants: A meta-analysis and meta-analysis of individual participant data

JA Agelink van Rentergem, NR de Vent… - Neuropsychology …, 2020‏ - Springer
Many neuropsychologists are of the opinion that the multitude of cognitive tests may be
grouped into a much smaller number of cognitive domains. However, there is little …

[HTML][HTML] A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer's prevention & treatment

A Mishra, Y Wang, F Yin, F Vitali, KE Rodgers… - Ageing research …, 2022‏ - Elsevier
Neurological aging is frequently viewed as a linear process of decline, whereas in reality, it
is a dynamic non-linear process. The dynamic nature of neurological aging is exemplified …