There is considerable evidence for induction of differential risk of noncommunicable
diseases in humans by variation in the quality of the early life environment. Studies in animal …

There is considerable evidence for the induction of different phenotypes by variations in the
early life environment, including nutrition, which in man is associated with a graded risk of …

Environmental constraints during early life result in phenotypic changes that can be
associated with increased disease risk in later life. This suggests persistent alteration of …

Prenatal nutritional constraint induces an altered metabolic phenotype in the offspring which
in humans confers an increased risk of non-communicable disease. Feeding a protein …

Complex traits, including those involved in diet-related diseases, are determined by multiple
genes and environmental influences. Factors influencing the development of complex traits …

The rapid increase in incidence of obesity over the past two decades cannot be explained
solely by genetic and adult lifestyle factors. There is now considerable evidence that the fetal …

Traditionally it has been widely accepted that our genes together with adult lifestyle factors
determine our risk of develo** non-communicable diseases such as type 2 diabetes …

Chronic diseases such as type 2 diabetes and cardiovascular disease are the leading cause
of death and disability worldwide. Although the metabolic syndrome has been defined in …

A number of epidemiological studies worldwide have demonstrated a relationship between
poor early growth and an increased susceptibility to insulin resistance, visceral obesity, type …

It is becoming increasingly apparent that conditions experienced in early life play an
important role in the long-term health of individuals. Alterations in development due to …