Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Naturally occurring plasmids come in different sizes. The smallest are less than a kilobase of
DNA, while the largest can be over three orders of magnitude larger. Historically, research …

Plasmids can mediate horizontal gene transfer of antibiotic resistance, virulence genes, and
other adaptive factors across bacterial populations. Here, we analyze genomic composition …

It is well established that plasmids play an important role in the dissemination of
antimicrobial resistance (AMR) genes; however, little is known about the role of the …

The presence of antibiotics can exert significant selection pressure on the emergence and
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …

Plasmids alter microbial evolution and lifestyles by mobilizing genes that often confer fitness
in changing environments across clades. Yet our ecological and evolutionary understanding …

Relaxase-based plasmid classification has become popular in the past 10 years.
Nevertheless, it is not obvious how to assign a query protein to a relaxase MOB family …

Antimicrobial resistance is a major threat for public health. Plasmids play a critical role in the
spread of antimicrobial resistance via horizontal gene transfer between bacterial species …

Plasmids are genetic elements that enable rapid adaptation and evolution by transferring
genes conferring selective advantages to their hosts. Conjugative plasmids are …

Plasmids are universally present in bacteria and play key roles in the dissemination of
genes such as antibiotic resistance determinants. Major concepts in Plasmid Biology derive …