In vitro Models of Bone Remodelling and Associated Disorders
Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance
between bone formation by osteoblasts and resorption by osteoclasts. Research into these …
between bone formation by osteoblasts and resorption by osteoclasts. Research into these …
Patient-derived xenograft models for endometrial cancer research
CP Moiola, C Lopez-Gil, S Cabrera, A Garcia… - International journal of …, 2018 - mdpi.com
Endometrial cancer (EC) is the most common malignancy of the genital tract among women
in developed countries. Recently, a molecular classification of EC has been performed …
in developed countries. Recently, a molecular classification of EC has been performed …
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
Aging is associated with distinct phenotypical, physiological, and functional changes,
leading to disease and death. The progression of aging-related traits varies widely among …
leading to disease and death. The progression of aging-related traits varies widely among …
Escape of hair follicle stem cells causes stem cell exhaustion during aging
Stem cell (SC) exhaustion is a hallmark of aging. However, the process of SC depletion
during aging has not been observed in live animals, and the underlying mechanism …
during aging has not been observed in live animals, and the underlying mechanism …
[HTML][HTML] Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation
H Wang, J Lu, T Stevens, A Roberts, J Mandel, R Avula… - Cell reports, 2023 - cell.com
MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …
Age-related decline in bone mineral transport and bone matrix proteins in osteoblasts from stromal stem cells
We studied osteoblast bone mineral transport and matrix proteins as a function of age. In
isolated bone marrow cells from long bones of young (3 or 4 mo) and old (18 or 19 mo) …
isolated bone marrow cells from long bones of young (3 or 4 mo) and old (18 or 19 mo) …
[HTML][HTML] Validation of finite element models of the mouse tibia using digital volume correlation
The mouse tibia is a common site to investigate bone adaptation. Micro-Finite Element
(microFE) models based on micro-Computed Tomography (microCT) images can estimate …
(microFE) models based on micro-Computed Tomography (microCT) images can estimate …
[HTML][HTML] The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse …
Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common
model for osteoporosis. However, a comprehensive in vivo assessment of intervention …
model for osteoporosis. However, a comprehensive in vivo assessment of intervention …
The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds
Background Brain aging is a major risk factor in the progression of cognitive diseases
including Alzheimer's disease (AD) and vascular dementia. We investigated a mouse model …
including Alzheimer's disease (AD) and vascular dementia. We investigated a mouse model …
[HTML][HTML] Self-adaptive deep learning-based segmentation for universal and functional clinical and preclinical CT image analysis
AW Zwijnen, L Watzema, Y Ridwan… - Computers in Biology …, 2024 - Elsevier
Background Methods to monitor cardiac functioning non-invasively can accelerate
preclinical and clinical research into novel treatment options for heart failure. However …
preclinical and clinical research into novel treatment options for heart failure. However …