Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a
central role in energy homeostasis and has been proposed as a therapeutic target in …

p38γ MAPK (also called ERK6 or SAPK3) is a family member of stress-activated MAPKs and
has common and specific roles as compared to other p38 proteins in signal transduction …

The heart, once considered a mere blood pump, is now recognized as a multifunctional
metabolic and endocrine organ. Its function is tightly regulated by various metabolic …

Heart failure and cancer are the leading cause of deaths worldwide. While heart failure and
cancer have been considered separate diseases, it is becoming evident that they are highly …

Stress-activated p38 kinases control a plethora of functions, and their dysregulation has
been linked to the development of steatosis, obesity, immune disorders, and cancer …

Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling
the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process …

Ventricular fibrillation (VF) is a leading immediate cause of sudden cardiac death. There is a
strong association between aging and VF, although the mechanisms are unclear, limiting …

Jellyfish stings have become a common injury among fishermen and divers. Severe jellyfish
stings could worsen cardiac function and even cause cardiac complications, ultimately …

Hypertrophic cardiomyopathy (HCM) is one of the most common cardiovascular diseases
with no effective treatment due to its complex pathogenesis. A novel cell death …

Aims Skeletal muscle, with its remarkable plasticity and dynamic adaptation, serves as a
cornerstone of locomotion and metabolic homeostasis in the human body. Muscle tissue …