BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

More than 60 years ago, the idea was introduced that NADH autofluorescence could be
used as a marker of cellular redox state and indirectly also of cellular energy metabolism …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

SUMMARY ANSWER: The present ESHRE document provides 11 recommendations on
how to introduce TLT in the IVF laboratory. WHAT IS KNOWN ALREADY: Studies have been …

Oocyte quality is a key factor influencing IVF success. The oocyte and surrounding cumulus
cells, known collectively as the cumulus oocyte complex (COC), communicate bi …

STUDY QUESTION Can label-free, non-invasive optical imaging by hyperspectral
autofluorescence microscopy discern between euploid and aneuploid cells within the inner …

Culling of day-old male chicks in production of laying hen strains involves several millions of
animals every year worldwide and is ethically controversial. In an attempt to provide an …

Detecting reactive oxygen species (ROS) that play a critical role as redox modulators and
signalling molecules in biological systems currently requires invasive methods such as ROS …

Islets prepared for transplantation into type 1 diabetes patients are exposed to
compromising intrinsic and extrinsic factors that contribute to early graft failure, necessitating …

Over the past 4 decades our ability to maintain a viable human embryo in vitro has improved
dramatically, leading to higher implantation rates. This has led to a notable shift to single …