The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

Abstract Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays
a central role in the coordination of postprandial glucose homeostasis through actions on …

The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

Objectives 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and
gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been …

The gastrointestinal tract maintains energy and glucose homeostasis, in part through
nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …