The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

Protein phosphorylation plays a central role in many biological and biomedical phenomena.
In this review, while a brief overview of the occurrence and function of protein …

The physiological state of the cell is controlled by signal transduction mechanisms which
regulate the balance between protein kinase and protein phosphatase activities. Here we …

The molecular basis of l-3, 4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID),
one of the major hindrances in the current therapy for Parkinson's disease, is still unclear …

Dopamine has been shown to stimulate phosphorylation of DARPP-32, a phosphoprotein
highly enriched in medium-sized spiny neurons of the neostriatum. Here, we investigated …

Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake
at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny …

A complex chain of intracellular signaling events, critically important in motor control, is
activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At …

Long-term potentiation (LTP) at the Schaffer collateral–CA1 synapse involves interacting
signaling components, including calcium (Ca2+)/calmodulin–dependent protein kinase II …

The brain dopaminergic system is a critical modulator of basal ganglia function and
plasticity. To investigate the contribution of the dopamine D1 receptor to this modulation, we …

Parkinson's disease (PD), a disorder caused by degeneration of the dopaminergic input to
the basal ganglia, is commonly treated with l-DOPA. Use of this drug, however, is severely …